New York University Organic Chemistry Ph.D. 2004
Columbia University NRSA-NIH Fellowship 2004-2005
Dr. Holmes and her students have developed a reliable detection assays that detect discrete optical changes arising from the reaction of small molecules such as drugs and abused narcotics with select organic compounds, now referred to as DETECHIP® sensors. Most recently, the technology was automated and miniaturized by using an in-house designed computer program to generate a unique 16-digit binary code that identifies the analyte based on overall color changes. For the miniaturized assay, Dip Pen Nanolithography (DPN®) and piezoelectric printing was used to print and link the sensors non-covalently onto or into solid polymeric matrices. Analytes were identified by using image software that analyzes RGB (red, green, blue) content and Genepix software for analyzing fluorescence changes.